Tretizen 20


Substance: Isotretinoin
Brand: zenlabs
Package: 20mg (10 capsules)



Tretizen-20 is a medicine used to treat severe acne that does not respond to other treatments, including antibiotics. This product is manufactured by the pharmaceutical company Zen Labs and contains the active ingredient isotretinoin. 13-cis-retinoic acid (isotretinoin) was first synthesized in 1955. In addition to acne, the indications for the use of the medicine are rosacea, perioral dermatitis, seborrheic dermatitis, folliculitis, granuloma annulare, sarcoidosis, various disorders of keratinization and photoaging.

Effect of isotretinoin

Isotretinoin stops the proliferation of epithelial cells of the sebaceous gland ducts, the formation of debris, facilitates their evacuation and normalizes terminal cell differentiation. Isotretinoin facilitates secretion and reduces sebum production.

Following oral administration, absorption of isotretinoin is variable, bioavailability is variable and low, taking isotretinoin with food increases bioavailability by 2-fold. The maximum concentration in the blood plasma is reached between 2 and 4 hours. Isotretinoin is 99.9% bound to plasma proteins (mainly albumin). The half-life of isotretinoin is 19 hours. Isotretinoin is excreted by the bile and the kidneys in approximately equal amounts.

Isotretinoin dosage for acne

Isotretinoin from Zen Labs is taken by mouth. The dosage regimen is established individually, because the adverse reactions and therapeutic efficacy of isotretinoin are dose-dependent and vary with each person. The drug is taken with food, the initial dose is 0.4-0.5 mg / kg per day, which is divided into two parts, and is used for 16-24 weeks.Depending on the severity of adverse reactions and response to treatment, dose adjustment is carried out.

Additional Information




20mg (10 capsules)




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